The 75- to 84-year age group had the greatest 10-year increase in total, structural, and load-dependent carotid artery stiffening compared with younger groups (P<0.05).
Cohort (n=2,604)
Yes
Structural stiffening accounts for the majority of age-related carotid artery stiffening, though load-dependent stiffening is highly variable and influenced by cardiovascular risk factors.
p-value: p=<0.05
Elastic arteries stiffen via 2 main mechanisms: (1) load-dependent stiffening from higher blood pressure and (2) structural stiffening due to changes in the vessel wall. Differentiating these closely coupled mechanisms is important to understanding vascular aging. MESA (Multi-Ethnic Study of Atherosclerosis) participants with B-mode carotid ultrasound and brachial blood pressure at exam 1 and exam 5 (year 10) were included in this study (n=2604). Peterson and Young elastic moduli were calculated to represent total stiffness. Structural stiffness was calculated by adjusting Peterson and Young elastic moduli to a standard blood pressure of 120/80 mm Hg with participant-specific models. Load-dependent stiffness was the difference between total and structural stiffness. Changes in carotid artery stiffness mechanisms over 10 years were compared by age groups with ANCOVA models adjusted for baseline cardiovascular disease risk factors. The 75- to 84-year age group had the greatest change in total, structural, and load-dependent stiffening compared with younger groups ( P <0.05). Only age and cessation of antihypertensive medication were predictive of structural stiffening, whereas age, race/ethnicity, education, blood pressure, cholesterol, and antihypertensive medication were predictive of increased load-dependent stiffening. On average, structural stiffening accounted for the vast majority of total stiffening, but 37% of participants had more load-dependent than structural stiffening. Rates of structural and load-dependent carotid artery stiffening increased with age. Structural stiffening was consistently observed, and load-dependent stiffening was highly variable. Heterogeneity in arterial stiffening mechanisms with aging may influence cardiovascular disease development.
Pewowaruk et al. (Mon,) conducted a cohort in Vascular aging and carotid artery stiffening (n=2,604). Aging (older age groups) vs. Younger age groups was evaluated on Changes in carotid artery stiffness mechanisms (total, structural, and load-dependent stiffening) over 10 years (p=<0.05). The 75- to 84-year age group had the greatest 10-year increase in total, structural, and load-dependent carotid artery stiffening compared with younger groups (P<0.05).