Key result
Coronary flow capacity was 3.1 cc/gm/min in normal men under 40, and was 30-37% lower in older individuals and in hypertrophied hearts over 600 gm compared to those under 350 gm.
Why the study?
Does cardiac hypertrophy and aging reduce the maximum capacity of the coronary bed in human hearts?
Population
Postmortem human hearts from normal men under 40, older adults, and middle-aged adults, including normal and…
Comparison
Postmortem perfusion of the coronary bed with… vs Comparisons across age groups and heart weights
Design
Other
Authors
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Postmortem data show lower maximal coronary flow with age and hypertrophy; leaves open whether these limits affect in vivo perfusion or outcomes.
Observational
Does cardiac hypertrophy and aging reduce the maximum capacity of the coronary bed in human hearts?
While coronary capacity decreases with age and cardiac hypertrophy, this may be a normal adaptation rather than a cause of anoxia-induced congestive failure.
William Dock (1941) conducted an observational in Cardiac hypertrophy. Cardiac hypertrophy and aging vs. Normal hearts and younger age was evaluated on Coronary flow capacity (cc. per gm. per minute at 100 mm. Hg). Coronary flow capacity was 3.1 cc/gm/min in normal men under 40, and was 30-37% lower in older individuals and in hypertrophied hearts over 600 gm compared to those under 350 gm.
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