Key result
Young age in lambs with aortic stenosis conferred advantages in coronary adaptation, maintaining normal capillary density and coronary conductance compared to adult sheep.
Why the study?
Does young age affect coronary adaptations to left ventricular pressure overload hypertrophy in sheep?
Population
Conscious chronically instrumented 10-week old lambs and adult sheep
Comparison
Progressive ascending aortic stenosis of… vs Age-matched control sheep
Design
Preclinical
Follow-up
6 weeks
Authors
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Young age may preserve coronary perfusion in hypertrophy; hypothesis-generating and leaves open clinical translation.
Does young age affect coronary adaptations to left ventricular pressure overload hypertrophy in sheep?
Young age in a sheep model confers advantages in coronary adaptation to left ventricular pressure overload, maintaining normal capillary density and coronary conductance compared to adults.
Flanagan et al. (1994) studied Left ventricular pressure overload hypertrophy. Young age (10-week old lambs) vs. Adult sheep was evaluated on Coronary conductance and capillary density. Young age in lambs with aortic stenosis conferred advantages in coronary adaptation, maintaining normal capillary density and coronary conductance compared to adult sheep.
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