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February 1, 1974Circulation ResearchOpen Access

Regional Myocardial Blood Flow in Lambs with Concentric Right Ventricular Hypertrophy

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Population

16 awake, 5-12-week-old, tranquilized lambs (9 with main pulmonary artery banded at 2 days of age, 7 controls)

Comparison

Main pulmonary artery banding at 2 days of age… vs Unbanded control lambs

Design

Preclinical

Authors

JAJoseph P. ArchieUniversidade da CoruñaDFDavid E. FixlerSouthwestern Medical CenterDUDaniel J. UllyotUniversity of California, San Francisco

Discussion

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Implication

Hypertrophied RV maintains vascular reserve without resting ischemia in lambs; leaves open translation to human pulmonary hypertension.

Structured PICO

P
Population
16 awake, 5-12-week-old, tranquilized lambs (9 with main pulmonary artery banded at 2 days of age, 7 controls)
I
Intervention
Main pulmonary artery banding at 2 days of age to induce concentric right ventricular hypertrophy
C
Comparator
Unbanded control lambs
O
Outcome
Magnitude and distribution of coronary blood flow, pressures, and cardiac output at rest and during stress states (isoproterenol and dextran infusion)surrogate

In a lamb model of right ventricular hypertrophy, hypertrophied right ventricular tissue maintains vascular reserve and is not ischemic at rest, though it may exhibit inefficient oxygen utilization.

Cite This Study

Archie et al. (1974) studied this question.

synapsesocial.com/papers/6a1757bf3510de12de8d7cd5https://doi.org/10.1161/01.res.34.2.143
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relation of ventricular volume, compliance, and mass in the normal and pulmonary arterial banded canine heart1972 · 39 citations
  2. 2Structural Basis for the Ascending Limb of Left Ventricular Function1973 · 98 citations
  3. 3Coronary Blood Flow and Myocardial Oxidative Metabolism at Rest and during Exercise in Subjects with Severe Aortic Valve Disease1965 · 44 citations
  4. 4Relationship Between Ventricular Pressures and Right and Left Myocardial Blood Flow1967 · 26 citations
  5. 5Effects of Renal Hypertension on Coronary Blood Flow, Cardiac Oxygen Consumption and Related Circulatory Dynamics of the Dog1959 · 29 citations