Key result
Coronary blood flow in pathological human hearts was markedly reduced to 0.15-0.6 cc per gram per minute compared to approximately 1.4 cc in normal hearts, and dilated hearts exhibited reversed responses to vasoactive drugs.
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Animal models inadequately replicate gradual human coronary sclerosis; leaves open need for improved translational systems.
Kountz et al. (1938) studied Chronic cardiac failure (n=15). Pathological heart conditions (hypertrophy and dilatation) vs. Normal hearts was evaluated on Coronary blood flow per gram of heart muscle per minute. Coronary blood flow in pathological human hearts was markedly reduced to 0.15-0.6 cc per gram per minute compared to approximately 1.4 cc in normal hearts, and dilated hearts exhibited reversed responses to vasoactive drugs.
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