Key result
Gradual constriction of the left circumflex coronary artery decreased reactive hyperemia and contractility, followed by increased flow in the unimpeded descending branch within 24 hours.
Experimental coronary insufficiency in dogs leads to compensatory increases in flow in unimpeded coronary branches, consistent with the rapid development of collateral circulation.
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Supports rapid collateral recruitment in experimental coronary constriction; leaves open translation to human coronary disease.
KHOURI et al. (1968) studied Experimental coronary insufficiency. Gradual constriction of the left circumflex coronary artery branch vs. Unimpeded descending coronary artery branch / baseline control was evaluated on Flow in the left circumflex and descending branches of the coronary artery, and cardiac contractility index. Gradual constriction of the left circumflex coronary artery decreased reactive hyperemia and contractility, followed by increased flow in the unimpeded descending branch within 24 hours.
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