What question did this study set out to answer?

The research aims to investigate the effects of circumflex branch constriction on coronary hemodynamics in conscious dogs.

February 1, 1968Circulation ResearchOpen Access

Day-to-Day Changes in Coronary Hemodynamics Secondary to Constriction of Circumflex Branch of Left Coronary Artery in Conscious Dogs

View Full Paper

Ask AI

Bookmark

The research aims to investigate the effects of circumflex branch constriction on coronary hemodynamics in conscious dogs.
Four dogs underwent procedures to apply ameroid constrictors to the circumflex branch.
Observations included measurements of circumflex blood flow and pressures over 16 to 64 days.
Circumflex branch occlusion was assessed with reactive hyperemia evaluations.
Circumflex blood flow reduced to zero in 5 to 10 days post-occlusion.
Mean peripheral circumflex pressure increased from normal to 60-70 mm Hg as blood flow decreased.
A maximum rate of rise in peripheral circumflex pressure varied from 6 to 15 mm Hg per 24 hours.

Structured PICO

Population

4 conscious dogs

Intervention

Application of ameroid constrictors to the circumflex branch of the left coronary artery

Outcome

Changes in circumflex blood flow, circumflex and peripheral circumflex pressures, circumflex reactive hyperemia and aortic-circumflex pressure differencesurrogate

Severe coronary insufficiency precedes a significant rise in mean peripheral circumflex pressure, indicating the opening of large collateral vessels following gradual coronary occlusion.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Severe coronary insufficiency precedes collateral opening in gradual occlusion; hypothesis-generating in animals, leaves open human CAD translation.

Cite This Study

Elliot et al. (1968) studied this question.

synapsesocial.com/papers/6a209011de5eb88fb8302345 https://doi.org/10.1161/01.res.22.2.237

View Full Paper

Ask AI

Bookmark

Implication

Severe coronary insufficiency precedes collateral opening in gradual occlusion; hypothesis-generating in animals, leaves open human CAD translation.

Day-to-Day Changes in Coronary Hemodynamics Secondary to Constriction of Circumflex Branch of Left Coronary Artery in Conscious Dogs

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Day-to-Day Changes in Coronary Hemodynamics Secondary to Constriction of Circumflex Branch of Left Coronary Artery in Conscious Dogs

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider