Key result
Constitutively active CaMKII increased Kv4.2 peak current density from 191.8 pA/pF to 422.9 pA/pF in transfected COS cells by increasing cell-surface expression of A-type potassium channels.
Absolute Event Rate: 422.9% vs 191.8%
p-value: p=<0.005
CaMKII directly modulates neuronal excitability by increasing cell-surface expression of A-type K(+) channels (Kv4.2).
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Reveals Kv4.2 as CaMKII substrate at Ser438/Ser459; leaves open effects on channel biophysics and excitability.
Varga et al. (2004) studied this question. Constitutively active CaMKII vs. GFP or wild-type without active CaMKII was evaluated on Peak current density of Kv4.2 (p=<0.005). Constitutively active CaMKII increased Kv4.2 peak current density from 191.8 pA/pF to 422.9 pA/pF in transfected COS cells by increasing cell-surface expression of A-type potassium channels.
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