Regulation of Kv4.3 currents by Ca2+/calmodulin-dependent protein kinase II

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Structured PICO

Population

Kv4.3 channels (wild-type and S550A mutants)

Intervention

Autothiophosphorylated CaMKII (10 nM) or CaMKII-inhibitory peptide/KN-93 via patch pipette

Comparator

Wild-type controls or baseline conditions

Outcome

Kv4.3 current inactivation rate, recovery from inactivation, and voltage dependencesurrogate

CaMKII directly regulates Kv4.3 currents by slowing inactivation and accelerating recovery via the S550A site at the COOH-terminal region.

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Extends CaMKII targets to Kv4.3 in vitro; leaves open its role in repolarization or arrhythmias pending in vivo validation.

Sergeant et al. (2004) studied this question.

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