Key result
The FII G20210A mutation increased stroke/TIA risk in men (OR 6.1; 95% CI 1.3-28.3; P=0.021), while factor V Leiden markedly increased stroke risk in female smokers (OR 8.8; 95% CI 2.0-38.0).
Why the study?
Do factor V Leiden and prothrombin G20210A mutations increase the risk of ischemic stroke or TIA in patients under 60 years of age?
Population
468 patients with an acute ischemic stroke or transient ischemic attack before the age of 60 years, and a…
Comparison
Presence of factor V Leiden mutation or… vs Healthy control population individually matched…
Design
Case-control
Authors
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FVL-smoking interaction may heighten stroke risk in young women; leaves open causal role and screening utility pending prospective data.
Case-Control (n=468)
Do factor V Leiden and prothrombin G20210A mutations increase the risk of ischemic stroke or TIA in patients under 60 years of age?
Odds Ratio: 6.1 (95% CI 1.3–28.3)
Absolute Event Rate: 6% vs 1%
p-value: p=0.021
The factor V Leiden mutation significantly increases stroke risk in female smokers under 60, while the prothrombin G20210A mutation increases stroke risk in men under 60.
Lalouschek et al. (2005) conducted a case-control in Ischemic stroke or transient ischemic attack (TIA) (n=468). Factor V Leiden and prothrombin G20210A mutations vs. Healthy control population individually matched for age and gender was evaluated on Risk of stroke/TIA associated with FII G20210A mutation in men (OR 6.1, 95% CI 1.3-28.3, p=0.021). The FII G20210A mutation increased stroke/TIA risk in men (OR 6.1; 95% CI 1.3-28.3; P=0.021), while factor V Leiden markedly increased stroke risk in female smokers (OR 8.8; 95% CI 2.0-38.0).
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