Key result
Stimulation of parenchymal sympathetic projections increased brown adipose tissue blood flow and thermogenesis, whereas stimulation of vascular projections improved glucose tolerance without altering thermogenesis.
Why the study?
Brown adipose tissue contributes to thermoregulation and glucose metabolism, but how these functions are coordinated remains unclear.
Population
Mice
Comparison
Chemogenetic activation of parenchymal vs vascular sympathetic projections to iBAT
Design
Preclinical experimental study
Authors
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May enable selective BAT modulation; leaves open whether distinct sympathetic circuits can be targeted in human metabolic disease.
Distinct subpopulations of sympathetic neurons in the stellate ganglion independently regulate thermogenesis and glucose metabolism in brown adipose tissue.
Neri et al. (2026) conducted a letter in Metabolic regulation (thermogenesis and glucose tolerance). Chemogenetic activation of sympathetic neurons (SG1/Rxfp1+ or SG2/Vmat1+) vs. Saline (SAL) was evaluated on iBAT temperature, blood flow, and blood glucose levels. Stimulation of parenchymal sympathetic projections increased brown adipose tissue blood flow and thermogenesis, whereas stimulation of vascular projections improved glucose tolerance without altering thermogenesis.
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