Key result
Viral retrograde tracing identifies iBAT-projecting postganglionic neurons in stellate and T2-T5 sympathetic ganglia in mice.
Why the study?
The sympathetic nervous system's role in activating brown fat and the need for functional mapping of its components to develop neuromodulation techniques motivated the study.
Population
Mouse model
Design
Pseudorabies virus retrograde tracing with whole tissue clearing and confocal/light sheet microscopy
Authors
Loading...
Mouse size limits anatomical SNS mapping of brown fat; larger models needed before neuromodulation strategies advance.
François et al. (2019) studied this question. Pseudorabies virus retrograde tracing and whole tissue clearing was evaluated on Location of pre- and postganglionic neurons innervating interscapular brown adipose tissue. Pseudorabies virus retrograde tracing and iDISCO whole tissue clearing identified iBAT projecting postganglionic neurons in the stellate/T1 and T2-T5 sympathetic chain ganglia in mice.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: