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A novel cytoplasmic delivery system of siRNA was developed by complexation between poly(ethylene glycol)-block-poly(2-(N,N-dimethylamino)ethyl methacrylate) copolymer (PEG–PAMA) and gold nanoparticles (GNPs), followed by the immobilization of siRNA bearing a thiol group (SH-siRNA). The PEGylated GNPs containing SH-siRNA showed a significant RNAi activity in HuH-7 cells.
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Oishi et al. (2006) studied this question.
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