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December 1, 1996The Journal of Experimental MedicineOpen Access

Viral Infection of Transgenic Mice Expressing a Viral Protein in Oligodendrocytes Leads to Chronic Central Nervous System Autoimmune Disease

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Key result

Intraperitoneal infection with LCMV in transgenic mice expressing viral proteins in oligodendrocytes induced chronic CNS autoimmune disease, which worsened after a second viral infection.

Why the study?

Does infection with a virus sharing epitopes with CNS antigens induce chronic CNS autoimmune disease in a transgenic mouse model?

Population

Transgenic mice expressing the nucleoprotein or glycoprotein of lymphocytic choriomeningitis virus as self…

Design

Preclinical

Authors

CEClaire F. EvansScripps Research InstituteMHMarc S. HorwitzUniversity of British ColumbiaMHM V HobbsScripps Research Institute

Discussion

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Implication

No immediate clinical implications; hypothesis-generating for viral triggers of human CNS autoimmunity.

Structured PICO

Does infection with a virus sharing epitopes with CNS antigens induce chronic CNS autoimmune disease in a transgenic mouse model?

P
Population
Transgenic mice expressing LCMV proteins in oligodendrocytes, infected with LCMV to study the induction of chronic CNS autoimmune disease.
I
Intervention
Intraperitoneal infection with LCMV strain Armstrong, followed by a second infection with LCMV or unrelated viruses
O
Outcome
Development of chronic CNS autoimmune disease (chronic inflammation, upregulation of MHC class I and II molecules, loss of myelin, and clinical motor dysfunction)surrogate

This study provides preclinical evidence supporting the molecular mimicry hypothesis, showing that viral infection can trigger and exacerbate chronic CNS autoimmune disease when viral epitopes are shared with host CNS proteins.

Cite This Study

Evans et al. (1996) studied Central nervous system autoimmune disease. Intraperitoneal infection with LCMV strain Armstrong was evaluated on Induction of chronic CNS inflammation and pathology. Intraperitoneal infection with LCMV in transgenic mice expressing viral proteins in oligodendrocytes induced chronic CNS autoimmune disease, which worsened after a second viral infection.

synapsesocial.com/papers/6a6ee481febe604dd70812e3https://doi.org/10.1084/jem.184.6.2371
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