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August 2, 2026BMC PediatricsOpen Access

Prevalence of hypocalcemia in neonates receiving phototherapy: a systematic review and meta-analysis

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Systematic review estimates hypocalcemia prevalence in neonates during phototherapy, suggesting increased monitoring is necessary.

This study aims to determine the prevalence of hypocalcemia in neonates receiving phototherapy for hyperbilirubinemia.
Conducted as a systematic review and meta-analysis following PRISMA guidelines.
Searched relevant databases for observational studies up to February 2026.
Analyzed data using a random effects model for pooled hypocalcemia prevalence with 95% confidence intervals.
Pooled prevalence of hypocalcemia in neonates undergoing phototherapy was 20.68% (95% CI: 15.75–25.60%).
Significant heterogeneity was observed with I² = 94.15%, p < 0.001.
Hypocalcemia rates were higher in preterm (23.03%) and low birth weight (22.57%) neonates compared to term (18.51%) and normal birth weight (13.97%).

Belayhun et al. (2026) studied this question.

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