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This review aims to evaluate the role of propofol in palliative sedation regarding symptom control, safety, and ethical implications.

August 2, 2026Palliative MedicineOpen Access

Propofol for palliative sedation: A systematic review of clinical outcomes, safety, and ethical implications

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Systematic review evaluates propofol's effectiveness and safety in palliative sedation, highlighting ethical concerns.

This review aims to evaluate the role of propofol in palliative sedation regarding symptom control, safety, and ethical implications.
Conducted a systematic review, registered in PROSPERO (CRD42025643575).
Searched Scopus, MEDLINE, and Web of Science for English-language studies from 2005 to 2024 involving propofol in terminally ill adults.
Included ten non-randomized studies focusing on propofol compared against other sedatives.
Symptom control achieved in 73%–100% of cases, with variable definitions and methods.
Target sedation depth reached in 52%–100% of instances.
Respiratory depression identified as the main safety concern, alongside ethical issues regarding consent.

Almeida-Jardim et al. (2026) studied this question.

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