Why the study?
Hypertrophic cardiomyopathy is associated with coronary microvascular dysfunction showing variable pathophysiologic mechanisms and variable reversibility acutely and chronically following alcohol septal ablation.
Does alcohol septal ablation improve immediate absolute coronary blood flow and coronary flow reserve in patients with hypertrophic obstructive cardiomyopathy?
Comparison
Immediately after ASA vs before ASA
Design
Single-center observational study
Follow-up
Immediately after ASA
Key result
Alcohol septal ablation in patients with hypertrophic obstructive cardiomyopathy produced no significant immediate change in mean coronary flow reserve (2.31 before vs. 2.35 after ASA; p=0.808).
Authors
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No immediate change in coronary flow reserve after alcohol septal ablation; leaves open whether delayed effects or clinical outcomes differ in hypertrophic obstructive cardiomyopathy.
Observational (n=23)
No
Does alcohol septal ablation improve immediate absolute coronary blood flow and coronary flow reserve in patients with hypertrophic obstructive cardiomyopathy?
Absolute Event Rate: 2.35% vs 2.31%
p-value: p=0.808
Alcohol septal ablation in hypertrophic obstructive cardiomyopathy does not produce immediate uniform improvements in coronary microvascular function, though a subset with lower baseline flow may experience improvement.
Misevic et al. (2026) conducted an observational in Hypertrophic Obstructive Cardiomyopathy (n=23). Alcohol Septal Ablation vs. Pre-ablation baseline was evaluated on Coronary flow reserve (CFR) (p=0.808). Alcohol septal ablation in patients with hypertrophic obstructive cardiomyopathy produced no significant immediate change in mean coronary flow reserve (2.31 before vs. 2.35 after ASA; p=0.808).