Key result
Alcohol septal ablation in patients with obstructive hypertrophic cardiomyopathy resulted in a 10-year survival of 88%, similar to the 84% survival in a matched background population (p=0.06).
Why the study?
Does alcohol septal ablation improve survival and reduce the risk of sudden cardiac death in patients with obstructive hypertrophic cardiomyopathy?
Population
470 consecutive patients with obstructive hypertrophic cardiomyopathy (HCM), mean age 56±14 years.
Comparison
Clinically applied echo-contrast-guided alcohol… vs Matched background population
Design
Cohort
Follow-up
8.4±4 years
Authors
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Survival after alcohol septal ablation matches background rates in obstructive HCM; supports use but leaves open randomized comparisons.
Cohort (n=470)
Yes
Does alcohol septal ablation improve survival and reduce the risk of sudden cardiac death in patients with obstructive hypertrophic cardiomyopathy?
Absolute Event Rate: 88% vs 84%
p-value: p=0.06
Alcohol septal ablation in patients with obstructive hypertrophic cardiomyopathy is associated with survival rates similar to the background population and a low incidence of sudden cardiac death.
Jensen et al. (2013) conducted a cohort in obstructive hypertrophic cardiomyopathy (n=470). Alcohol septal ablation (ASA) vs. Matched background population was evaluated on All-cause mortality (p=0.06). Alcohol septal ablation in patients with obstructive hypertrophic cardiomyopathy resulted in a 10-year survival of 88%, similar to the 84% survival in a matched background population (p=0.06).
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