November 18, 1997Circulation
Effects of Dobutamine at Maximally Tolerated Dose on Myocardial Blood Flow in Humans With Ischemic Heart Disease
Key result
Myocardial blood flow responses to dobutamine and adenosine are linearly correlated over a wide range in patients with ischemic heart disease (r=0.78, P<.0001).
Why the study?
Does dobutamine at maximally tolerated dose produce a myocardial blood flow response correlated with adenosine in patients with ischemic heart disease?
Population
13 humans (11 men, 2 women) with ischemic heart disease
Comparison
Dobutamine at maximally tolerated dose vs Adenosine and resting baseline
Design
Cross-sectional
Authors
Discussion
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Implication
May support dobutamine MBF assessment in adenosine-intolerant IHD; leaves open prospective validation.
Study Design
Type
Observational (n=13)
Structured PICO
Does dobutamine at maximally tolerated dose produce a myocardial blood flow response correlated with adenosine in patients with ischemic heart disease?
P
Population
13 patients (11 men, 2 women) with ischemic heart disease undergoing PET imaging to measure myocardial blood flow at rest and during pharmacological stress.
E
Exposure
Dobutamine at maximally tolerated dose
C
Comparator
Adenosine and resting baseline
O
Outcome
Myocardial blood flow measured by PET with [13N]ammoniasurrogate
Main Result
Effect estimate: r=0.78
p-value: p=<.0001
In patients with ischemic heart disease, myocardial blood flow responses to dobutamine and adenosine are linearly correlated, and dobutamine induces coronary steal at a frequency approaching that of adenosine.
Cite This Study
Skopicki et al. (1997) conducted an observational in Ischemic heart disease (n=13). Dobutamine vs. Adenosine and rest was evaluated on Correlation between myocardial blood flow response to dobutamine and adenosine (r=0.78, p=<.0001). Myocardial blood flow responses to dobutamine and adenosine are linearly correlated over a wide range in patients with ischemic heart disease (r=0.78, P<.0001).