What question did this study set out to answer?

To assess the efficacy of TissueDerm Graft® as a dermal substitute in full-thickness skin defects compared to Matriderm®.

August 2, 2026PolymersOpen Access

Wound Healing Efficacy of Novel Dermal Substitute TissueDerm Graft® in Full-Thickness Skin Defects

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Randomized trial compares TissueDerm Graft and Matriderm in wound healing of skin defects, suggesting improved outcomes.

To assess the efficacy of TissueDerm Graft® as a dermal substitute in full-thickness skin defects compared to Matriderm®.
Full-thickness skin defects were induced in minipigs.
TissueDerm Graft® and Matriderm® were co-implanted with split-thickness skin grafts (STSG).
Wound healing properties and aesthetic outcomes were compared post-treatment.
TissueDerm Graft® showed improved visual outcomes over STSG alone and STSG with Matriderm®.
Wound healing was favorable with minimal inflammatory responses and scar formation.

Shim et al. (2026) studied this question.

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