Key result
Histology of a placenta infected with T. cruzi from a Brazilian woman in Ireland showed lymphocytic chorioamnionitis with multinucleated giant cells, cord vasculitis, and funisitis.
Why the study?
Chagas disease is an increasing public health concern in non-endemic countries due to population movements, with few reported cases of vertical transmission in non-endemic settings.
Case Report (n=1)
Answers are grounded in this paper and cite their sources.
Highlights the potential for vertical transmission of Chagas disease in non-endemic countries due to population movements and describes the associated placental histology.
Chagas disease, once confined to rural Latin America is an increasing public health concern in non-endemic countries due to population movements. Here we present an unexpected finding of a placenta infected with T. cruzi from a Brazilian woman residing in Ireland. Histology of the placenta showed a lymphocytic chorioamnionitis with multinucleated giant cells (MNGCs) as well as cord vasculitis and funisitis. Amastigotes of trypanosomiasis were found in both cord and membranes. The placenta parenchyma, however, had no villitis or amastigotes and maturation was appropriate for gestation. To date, there have been few reported cases of vertical transmission in non-endemic countries. We discuss the histological findings and review the literature on potential modes of transmission from mother to fetus.
No takes yet. Share an insight, caveat, or question.
Keogh et al. (2021) conducted a case report in Chagas disease (T. cruzi infection) (n=1). T. cruzi infection was evaluated on Histological findings of the infected placenta. Histology of a placenta infected with T. cruzi from a Brazilian woman in Ireland showed lymphocytic chorioamnionitis with multinucleated giant cells, cord vasculitis, and funisitis.
Synapse has enriched 10 related papers. Consider them for comparative context: