Key result
The prostaglandin E2-EP4 axis promotes adipose tissue lipolysis and fibrosis leading to insulin resistance, whereas its perturbation leads to metabolically healthy obesity.
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Design
Genotype-phenotype association analyses
EP4 modulation may promote metabolically healthy obesity; leaves open therapeutic targeting pending clinical validation.
-EP4 pathway sustains basal lipolysis as a negative feedback loop of insulin action, and perturbation of this process leads to "metabolically healthy obesity." The potential role of the human EP4 receptor in lipid regulation was also suggested through genotype-phenotype association analyses.
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Inazumi et al. (2020) studied this question. The prostaglandin E2-EP4 axis promotes adipose tissue lipolysis and fibrosis leading to insulin resistance, whereas its perturbation leads to metabolically healthy obesity.
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