Key result
The FTO gene variant rs9939609 risk allele A was significantly associated with an increased risk of polycystic ovary syndrome in Chinese women (OR 1.44), an effect that remained significant even after adjustment for body mass index.
Why the study?
Is the FTO gene variant rs9939609 associated with an increased risk of Polycystic Ovary Syndrome in Han Chinese women?
Case-Control (n=6,681)
No
Is the FTO gene variant rs9939609 associated with an increased risk of Polycystic Ovary Syndrome in Han Chinese women?
Odds Ratio: 1.44 (95% CI 1.3–1.6)
Absolute Event Rate: 13.9% vs 10.1%
p-value: p=1.26E-11
The FTO gene variant rs9939609 is associated with an increased risk of PCOS in Chinese women, independent of obesity.
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May aid PCOS risk stratification; extends replicated genetic associations across populations.
Li et al. (2013) conducted a case-control in Polycystic Ovary Syndrome (PCOS) (n=6,681). FTO gene variant rs9939609 (risk allele A) vs. Major allele T was evaluated on Association of FTO rs9939609 with PCOS susceptibility (OR 1.44, 95% CI 1.30-1.60, p=1.26E-11). The FTO gene variant rs9939609 risk allele A was significantly associated with an increased risk of polycystic ovary syndrome in Chinese women (OR 1.44), an effect that remained significant even after adjustment for body mass index.
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