Key result
The FABP2-T54 allele (OR 1.51) and APOE4 isoform (OR 1.89) were associated with a significantly increased risk of past history of myocardial infarction.
Why the study?
Are FABP2 A54T and APOE isoforms associated with a history of myocardial infarction, stroke, diabetes, and gallbladder disease?
Observational (n=1,492)
Are FABP2 A54T and APOE isoforms associated with a history of myocardial infarction, stroke, diabetes, and gallbladder disease?
FABP2-T54 and APOE4 alleles are associated with an increased risk of myocardial infarction, with APOE4 showing sex-dependent effects.
Answers are grounded in this paper and cite their sources.
Should not yet change clinical risk stratification for myocardial infarction; leaves open whether FABP2 and APO.
Dysfunctional lipid metabolism plays a central role in pathogenesis of major chronic diseases, and genetic factors are important determinants of individual lipid profiles. We analyzed the associations of two well-established functional polymorphisms (FABP2 A54T and APOE isoforms) with past and family histories of 1492 population samples. FABP2-T54 allele was associated with an increased risk of past history of myocardial infarction (odds ratio (OR) = 1.51). Likewise, the subjects with APOE4, compared with E2 and E3, had a significantly increased risk of past history myocardial infarction (OR = 1.89). The OR associated with APOE4 was specifically increased in women for past history of myocardial infarction but decreased for gallstone disease. Interactions between gender and APOE isoforms were also significant or marginally significant for these two conditions. FABP2-T54 allele may be a potential genetic marker for myocardial infarction, and APOE4 may exert sex-dependent effects on myocardial infarction and gallbladder disease.
No takes yet. Share an insight, caveat, or question.
Kato et al. (2011) conducted an observational in Myocardial infarction, stroke, diabetes, and gallbladder disease (n=1,492). FABP2-T54 allele and APOE4 isoform vs. Non-carriers (e.g., APOE E2 and E3) was evaluated on Past history of myocardial infarction (OR 1.51). The FABP2-T54 allele (OR 1.51) and APOE4 isoform (OR 1.89) were associated with a significantly increased risk of past history of myocardial infarction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: