Key result
FABP2 Ala54Thr polymorphism linked to ~55% greater risk of atherothrombotic cerebral infarction in metabolic syndrome.
Why the study?
Genetic variants that confer susceptibility to atherothrombotic cerebral infarction among individuals with metabolic syndrome were not well identified.
Are specific genetic variants associated with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome?
Population
1284 unrelated Japanese individuals with metabolic syndrome including 313 with atherothrombotic cerebral infarction and 971 controls
Comparison
Genotypes of 296 polymorphisms in 202 candidate genes in cases versus controls
Design
Case-control study
Authors
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May inform genetic risk stratification in metabolic syndrome; leaves open validation and clinical utility in diverse populations.
Case-Control (n=1,284)
Yes
Are specific genetic variants associated with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome?
Odds Ratio: 1.55 (95% CI 1.16–2.07)
p-value: p=0.0031
Specific genetic variants, particularly in the FABP2 gene, may help predict the risk of atherothrombotic cerebral infarction in Japanese patients with metabolic syndrome.
Yamada et al. (2008) conducted a case-control in Atherothrombotic cerebral infarction in metabolic syndrome (n=1,284). FABP2 2445G→A (Ala54Thr) polymorphism vs. Wild-type GG genotype was evaluated on Prevalence of atherothrombotic cerebral infarction (OR 1.55, 95% CI 1.16-2.07, p=0.0031). The 2445G→A (Ala54Thr) polymorphism of FABP2 was significantly associated with an increased risk of atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome (OR 1.55).
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