The metabolomic blood analysis can be used in clinical laboratory practice to improve the efficiency of diagnostics and risk assessment of diseases, since the current clinical diagnostics is not able to cope with the full range of possible human diseases. According to the latest advances in analytical and computational tools, not more than 1 l of blood is required for metabolic analysis. Therefore, the dried blood spot method is a low invasive method and allows collecting samples with ease of manipulation and minimal costs. In addition, samples can be collected outside the laboratory at home. This review details the dry blood drop method for obtaining a sample for the metabolomic analysis of blood. The review also describes the use of dried blood spot in the workflow with the metabolome blood analysis by direct mass spectrometry, which includes direct injection of extracted from the spot metabolites into the ionization source of quadrupole time-of-flight mass spectrometer
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Balashova et al. (2018) studied this question.
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