Evaluation of the efficacy of EGF and hyaluronic acid formulation on periodontal defects named also black holes

Background: The aim of this study was to determine the efficacy of the application of a formula composed by EGF and Hyaluronic acid 1% emulsion on periodontal defects or black holes.This clinical trial was approved by the ethical committees in research of University of Granada and carried out according to the Declaration of Helsinki.The study was clinically registered with number 6/CEIH/2015. Materials and Methods:In this randomized controlled clinical study, data from 23 individuals with chronic periodontitis were evaluated after full-mouth SRP.In the test group (0) (n = 11), EGF-hyaluronic 1% emulsion was additionally applied during 10 session.The control group (1) (n = 12) was treated with SRP only and hyaluronic acid 1% gel.The results were statistically examined.Results: Descriptive variables frequencies were calculated with patient's information.Group 0 sample size was 41 black holes analysed.Difference mean of probing depth was higher at 6 months.Group 1 sample size was 50 black holes.PD (mm) I-3P is positioned lower than PD I-3P.After 6 months decreasing was higher in both groups than after 3 months.CAL I-6P had a displacement to the bottom respect to I-3P but population median is the same.CAL I-6P of group 1 is more disperse than I-3P.Wilcoxon test was significative when (P ≤ 0.05).Mann-Whitney U-test indicated significance between groups.Conclusion: Both treatments 1%HA-EGF emulsion and 1%HA gel increase gingival and bone tissue.