Key result
High admission plasma concentrations of branched-chain amino acids were independently associated with an increased risk of in-hospital cardiovascular death or acute heart failure (OR 3.36 per 1-SD increase).
Why the study?
Are high circulating BCAA concentrations on admission associated with increased risk of in-hospital adverse cardiovascular events in patients with STEMI treated with PCI?
Population
192 patients with STEMI treated with primary PCI, comprising 96 who developed post-PCI adverse events and 96…
Comparison
High circulating branched chain amino acid… vs Low/normal BCAA concentrations
Design
Case-control
Follow-up
in-hospital
Authors
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May refine GRACE-based risk prediction in STEMI; leaves open causality and therapeutic targeting.
Case-Control (n=192)
No
Are high circulating BCAA concentrations on admission associated with increased risk of in-hospital adverse cardiovascular events in patients with STEMI treated with PCI?
Odds Ratio: 3.36 (95% CI 1.98–5.69)
p-value: p=<0.001
High circulating BCAA concentrations on admission are associated with subsequent in-hospital adverse events and significantly improve risk prediction when added to the GRACE score in STEMI patients undergoing PCI.
Du et al. (2018) conducted a case-control in ST-segment elevation myocardial infarction (STEMI) (n=192). High circulating branched chain amino acid (BCAA) concentrations vs. Lower BCAA concentrations was evaluated on Composite of cardiovascular death and acute heart failure during hospitalization (OR 3.36, 95% CI 1.98-5.69, p=<0.001). High admission plasma concentrations of branched-chain amino acids were independently associated with an increased risk of in-hospital cardiovascular death or acute heart failure (OR 3.36 per 1-SD increase).
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