Key result
A 7-year-old boy with familial hypercholesterolemia type IIb and extreme hyperlipidemia developed premature atherosclerosis in the aortic valve.
Case Report (n=1)
This case report highlights the potential for severe, early-onset aortic valve atherosclerosis in pediatric patients with familial hypercholesterolemia.
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May warrant aortic valve screening in severe pediatric FH; leaves open optimal management and prospective validation.
To the Editor: We report a case of atherosclerosis in the aortic valve of a seven-year-old boy with familial hypercholesterolemia. This boy, born on August 7, 1949, had familial hypercholesterolemia type IIb and asthma. At birth, he had prominent cutaneous xanthomas along the extensor surfaces of his arms and legs, gluteal folds, and Achilles tendons. His serum lipid levels were as follows: cholesterol, 951 mg per deciliter; cholesterol esters, 666 mg per deciliter; fatty acids, 1032 mg per deciliter; and phospholipids, 600 mg per deciliter. On October 31, 1956, the boy was hospitalized for the evaluation of acute cyanosis and . . .
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Rajamannan et al. (2003) conducted a case report in Familial hypercholesterolemia type IIb and aortic valve atherosclerosis (n=1). Familial hypercholesterolemia type IIb was evaluated. A 7-year-old boy with familial hypercholesterolemia type IIb and extreme hyperlipidemia developed premature atherosclerosis in the aortic valve.
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