Key result
The combination of current smoking and a family history of aneurysmal subarachnoid hemorrhage synergistically increased the risk of the disease (OR 6.4) beyond an additive model.
Why the study?
Does the combination of current smoking and family history synergistically increase the risk of aneurysmal subarachnoid hemorrhage?
Case-Control (n=1,355)
Yes
Does the combination of current smoking and family history synergistically increase the risk of aneurysmal subarachnoid hemorrhage?
Odds Ratio: 6.4 (95% CI 3.1–13.2)
p-value: p=<0.0001
There is a significant gene-environment interaction between smoking and family history that synergistically increases the risk of aneurysmal subarachnoid hemorrhage.
No takes yet. Share an insight, caveat, or question.
Supports smoking-family history interaction on aSAH risk; hypothesis-generating and requires prospective confirmation before clinical adoption.
Woo et al. (2009) conducted a case-control in Aneurysmal subarachnoid hemorrhage (n=1,355). Current smoking and family history of aSAH vs. Current nonsmokers with no family history of aSAH was evaluated on Aneurysmal subarachnoid hemorrhage (OR 6.4, 95% CI 3.1-13.2, p=<0.0001). The combination of current smoking and a family history of aneurysmal subarachnoid hemorrhage synergistically increased the risk of the disease (OR 6.4) beyond an additive model.
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