Key result
Smoking plus hypertension significantly increased the risk of intracranial aneurysm in first-degree relatives of patients with familial subarachnoid haemorrhage (RR 2.7; 95% CI 1.4 to 5.3).
Why the study?
Do smoking and hypertension increase the risk of intracranial aneurysms in first-degree relatives of patients with familial subarachnoid haemorrhage?
Observational
Do smoking and hypertension increase the risk of intracranial aneurysms in first-degree relatives of patients with familial subarachnoid haemorrhage?
Effect estimate: RR 2.7 (95% CI 1.4 to 5.3)
Smoking and hypertension significantly increase the risk of intracranial aneurysms in individuals with a family history of subarachnoid hemorrhage, highlighting the importance of risk factor modification in this high-risk population.
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May support risk stratification in familial SAH relatives; hypothesis-generating and requires prospective confirmation before practice change.
Rasing et al. (2012) conducted an observational in Familial subarachnoid haemorrhage. Smoking and hypertension vs. Absence of smoking and hypertension was evaluated on Presence of an intracranial aneurysm (RR 2.7, 95% CI 1.4 to 5.3). Smoking plus hypertension significantly increased the risk of intracranial aneurysm in first-degree relatives of patients with familial subarachnoid haemorrhage (RR 2.7; 95% CI 1.4 to 5.3).
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