Why the study?
Preventive screening for intracranial aneurysms in persons with a positive family history of aneurysmal subarachnoid hemorrhage is cost-effective but not very efficient.
Does the NASH score accurately predict the presence of intracranial aneurysms at first screening in persons with a family history of subarachnoid hemorrhage?
Population
660 development and 258 validation persons with ≥2 affected first-degree relatives
Design
Prospective cohort prediction model development and external validation study
Authors
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May refine IA screening efficiency in familial SAH; leaves open effects on rupture prevention.
Does the NASH score accurately predict the presence of intracranial aneurysms at first screening in persons with a family history of subarachnoid hemorrhage?
The NASH score, based on 4 easily retrievable predictors, provides risk estimates for intracranial aneurysms at first screening to help guide preventive screening decisions in high-risk individuals.
Zuurbier et al. (2022) studied this question.
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