Key result
Screening first-degree relatives of patients with sporadic subarachnoid hemorrhage yielded a 4.0% aneurysm prevalence and required 149 screens to prevent one hemorrhage, not offsetting surgical risks.
Why the study?
Does screening for intracranial aneurysms using MRA improve life expectancy and prevent subarachnoid hemorrhage in first-degree relatives of patients with sporadic subarachnoid hemorrhage?
Population
626 first-degree relatives of 160 patients with sporadic subarachnoid hemorrhage
Design
Cohort
Follow-up
6 months after elective operation
Authors
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Screening may identify treatable aneurysms in relatives; leaves open net benefit versus harm pending prospective trials.
Observational (n=626)
Does screening for intracranial aneurysms using MRA improve life expectancy and prevent subarachnoid hemorrhage in first-degree relatives of patients with sporadic subarachnoid hemorrhage?
Number Needed to Treat: 149
Screening first-degree relatives of patients with sporadic subarachnoid hemorrhage is not warranted because the risks of postoperative neurologic deficits outweigh the slight increase in life expectancy.
The Magnetic Resonance Angiography in Relatives of Patients with Subarachnoid Hemorrhage Study Group (1999) conducted an observational in First-degree relatives of patients with sporadic subarachnoid hemorrhage (n=626). Screening for intracranial aneurysms was evaluated on Aneurysm prevalence (95% CI 2.6 to 5.8). Screening first-degree relatives of patients with sporadic subarachnoid hemorrhage yielded a 4.0% aneurysm prevalence and required 149 screens to prevent one hemorrhage, not offsetting surgical risks.
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