Key result
A daily premature ventricular contraction burden of 15.59% or higher predicted left ventricular diastolic dysfunction with 88.9% sensitivity and 66.7% specificity.
Why the study?
While tachycardiomyopathy causing reduced LV systolic function is recognized, the effects of idiopathic premature ventricular contractions on LV diastolic function remained to be investigated.
Does PVC burden predict left ventricular diastolic dysfunction in patients with idiopathic PVCs?
Cross-Sectional (n=63)
Does PVC burden predict left ventricular diastolic dysfunction in patients with idiopathic PVCs?
In patients with idiopathic PVCs, a PVC burden >15.59% is a strong predictor of left ventricular diastolic dysfunction.
Higher PVC burden correlated with worse LV diastolic parameters; leaves open whether ablation improves diastolic function in idiopathic PVCs.
Objectives: Tachycardiomyopathy is a well-known phenomenon with reduction in left ventricular (LV) systolic function. In our study, we aimed to investigate the effects of idiopathic premature ventricular contractions (PVCs) on LV diastolic function in patients with idiopathic PVCs. Methods: We included 63 patients who are candidates to undergo radiofrequency ablation due to idiopathic PVCs (27 male, 36 female; mean age 47.9 ±16.6 years). Patients were classified into two groups according to the presence of LV diastolic dysfunction. The percentage of PVC burden was calculated by dividing the daily PVC burden by the total heart beat per day. Coupling interval ratio was calculated with the formula of Coupling interval ratio = (Coupling interval/sinus cycle length)x100. Results: Age, presence of q wave in D2-D3, daily PVC burden, percentage of PVC burden, left atrial volume index, intervenricular septum thickness, and mitral E/e’ ratio were significantly higher; male gender, peak E-wave velocity, lateral and septal annular e' velocity were significantly lower in patients with LV diastolic dysfunction. Daily PVC burden and percentage of PVC burden were positively correlated with mitral E/e’ ratio and negatively correlated with lateral annular e' velocity. The coupling interval ratio was positively correlated with mitral E/e’ ratio. Age, daily PVC burden, and percentage of PVC burden were independent predictors of increased mitral E/e’ ratio. The cutoff value of the percentage of PVC burden was 15.59% for prediction of LV diastolic dysfunction (sensitivity: 88.9%, specificity: 66.7%). Conclusions: Daily PVC burden, percentage of PVC burden, and coupling interval ratio are correlated with echocardiographic parameters of LV diastolic function.
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Kaypaklı et al. (2024) conducted a cross-sectional in Idiopathic premature ventricular contractions (n=63). Premature ventricular contraction (PVC) burden vs. Lower PVC burden was evaluated on Left ventricular diastolic dysfunction (AUC 0.745, p=0.032). A daily premature ventricular contraction burden of 15.59% or higher predicted left ventricular diastolic dysfunction with 88.9% sensitivity and 66.7% specificity.
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