Key result
The matrix protein (M1) of influenza A virus specifically binds single-stranded RNA, forming stable complexes sensitive to pH and salt concentration.
Population
Influenza A virus matrix protein M1
Design
Preclinical
Authors
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May guide antivirals targeting M1-RNA interactions; extends NP parallels but leaves open in vivo roles.
The influenza A virus matrix protein M1 specifically binds single-stranded RNA, forming stable complexes, which may relate to its role in viral assembly and transcriptase inhibition.
Wakefield et al. (1989) studied Influenza A virus. Influenza A virus matrix protein M1 was evaluated on RNA-binding properties. The matrix protein (M1) of influenza A virus specifically binds single-stranded RNA, forming stable complexes sensitive to pH and salt concentration.
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