Key result
Endothelin-1 and ET-3 exerted strong positive inotropic effects in human myocardial trabeculae, mediated by both ETA and ETB receptors.
Why the study?
Do endothelin ETA and ETB receptors mediate positive inotropic responses in human myocardial trabeculae?
Population
Isolated myocardial trabeculae from human hearts (right atrium and left ventricle)
Comparison
Endothelin-1, ET-3, ETA receptor antagonist… vs Responses without antagonists or baseline…
Design
Preclinical
Authors
Loading...
ET receptor agonism may enhance contractility in isolated human myocardium; leaves open in vivo relevance and therapeutic targeting.
Do endothelin ETA and ETB receptors mediate positive inotropic responses in human myocardial trabeculae?
Both ETA and ETB receptors mediate positive inotropic responses at both the atrial and ventricular levels in the human heart.
Opgaard et al. (2000) studied this question. Endothelin-1 and ET-3 was evaluated on Isometric contractile force. Endothelin-1 and ET-3 exerted strong positive inotropic effects in human myocardial trabeculae, mediated by both ETA and ETB receptors.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: