Key result
Tetracaine (25-200 microM) partially inhibited calcium-induced calcium release, initially abolishing spontaneous Ca2+ release before it returned at a lower frequency but greater amplitude, increasing SR Ca2+ content.
Partial inhibition of calcium-induced calcium release by tetracaine increases sarcoplasmic reticulum Ca2+ content in rat ventricular myocytes.
No takes yet. Share an insight, caveat, or question.
Tetracaine transiently suppresses then alters spontaneous Ca²⁺ release in overloaded myocytes; leaves open relevance to human Ca²⁺-triggered arrhythmias.
Overend et al. (1997) studied Ca2+ overload in rat ventricular myocytes. Tetracaine vs. Control (absence of tetracaine) was evaluated on Spontaneous Ca2+ release and sarcoplasmic reticulum (SR) Ca2+ content. Tetracaine (25-200 microM) partially inhibited calcium-induced calcium release, initially abolishing spontaneous Ca2+ release before it returned at a lower frequency but greater amplitude, increasing SR Ca2+ content.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: