Population
Isolated rat ventricular myocytes and cardiac SR Ca(2+)-release channels incorporated into lipid bilayers
Comparison
Tetracaine vs Control conditions
Design
Preclinical
Authors
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Tetracaine's concentration-dependent effects on myocyte Ca2+ release should not alter clinical practice; hypothesis-generating for SR handling in arrhythmia models.
Tetracaine exhibits a dual effect on spontaneous calcium release in rat ventricular myocytes, primarily inhibiting SR Ca2+-release channels but causing late potentiation at submaximal doses due to increased SR Ca2+ load.
Györke et al. (1997) studied this question.
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