Key result
The CXCL9 rs10336 CC genotype was associated with a significantly reduced risk of severe ventricular dysfunction in patients with chronic Chagas cardiomyopathy (OR 0.47).
Population
Myocardial samples from end-stage Chronic Chagas cardiomyopathy patients and a cohort of Chagas disease…
Design
Cohort
Authors
Loading...
May support genetic risk stratification in Chagas cardiomyopathy; hypothesis-generating and requires prospective validation.
Observational (n=325)
Odds Ratio: 0.47 (95% CI 0.25–0.87)
p-value: p=0.01
Polymorphisms in CXCL9 and CXCL10 are associated with the intensity of myocarditis and clinical progression to ventricular dysfunction in Chagas cardiomyopathy.
Nogueira et al. (2012) conducted an observational in Chronic Chagas Cardiomyopathy (n=325). CXCL9 rs10336 CC genotype vs. CXCL9 rs10336 TT or TC genotypes was evaluated on Severe Chronic Chagas Cardiomyopathy (LVEF ≤40%) (OR 0.47, 95% CI 0.25-0.87, p=0.01). The CXCL9 rs10336 CC genotype was associated with a significantly reduced risk of severe ventricular dysfunction in patients with chronic Chagas cardiomyopathy (OR 0.47).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: