Key result
Among male patients with pure autonomic failure, the presence of supine hypertension was associated with a significantly lower estimated glomerular filtration rate (57 vs 70 mL/min per 1.73 m2; P=0.022).
Case-Control (n=139)
No
Absolute Event Rate: 57% vs 70%
p-value: p=0.022
Pure autonomic failure is associated with diminished renal function and lower hemoglobin levels, particularly in patients with concurrent supine hypertension.
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Signals potential renal vulnerability in pure autonomic failure; leaves open whether supine hypertension treatment preserves GFR.
Garland et al. (2009) conducted a case-control in Pure Autonomic Failure (n=139). Supine hypertension vs. No supine hypertension was evaluated on Estimated glomerular filtration rate (mL/min per 1.73 m2) (p=0.022). Among male patients with pure autonomic failure, the presence of supine hypertension was associated with a significantly lower estimated glomerular filtration rate (57 vs 70 mL/min per 1.73 m2; P=0.022).
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