Key result
External application of 20 microM ethyl oleate to Sf9 cells expressing Kv1.1 channels decreased macroscopic current rise times from 51.7 to 12.8 ms.
Population
Sf9 cells expressing recombinant human brain delayed rectifier potassium channel Kv1.1, and rat hippocampal…
Comparison
External application of ethyl oleate or… vs Application of ethanol alone, oleic acid alone…
Design
Preclinical
Authors
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May link FAEEs to ethanol effects on Kv1.1; leaves open in vivo relevance.
Absolute Event Rate: 12.8% vs 51.7%
Fatty acid ethyl esters, nonoxidative metabolites of ethanol, significantly accelerate the activation kinetics of the neuronal Kv1.1 potassium channel, potentially contributing to the pathophysiologic effects of ethanol abuse.
Gubitosi‐Klug et al. (1996) studied this question. Ethyl oleate (fatty acid ethyl esters) vs. Baseline was evaluated on Rise times of the macroscopic current (10-90% rise times at 0 mV). External application of 20 microM ethyl oleate to Sf9 cells expressing Kv1.1 channels decreased macroscopic current rise times from 51.7 to 12.8 ms.
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