Key result
Ethanol, chlorpromazine, and hypertonicity multiply miniature end-plate potential frequency independently of calcium, implying a final common pathway for transmitter secretion requiring little or no calcium.
Population
Preclinical model of transmitter secretion (specific model not stated in abstract)
Design
Preclinical
Authors
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Should not alter ethanol-related clinical practice; leaves open a calcium-independent final common pathway for transmitter secretion.
The findings suggest a final common pathway for transmitter secretion that requires little or no calcium.
Quastel et al. (1971) studied this question. Ethanol, chlorpromazine, and hypertonicity was evaluated on Transmitter secretion (miniature end-plate potential frequency and depolarization-evoked quantal release). Ethanol, chlorpromazine, and hypertonicity multiply miniature end-plate potential frequency independently of calcium, implying a final common pathway for transmitter secretion requiring little or no calcium.
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