February 1, 1968The Journal of PhysiologyOpen Access

On the mechanism by which calcium and magnesium affect the spontaneous release of transmitter from mammalian motor nerve terminals

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Population

Rat diaphragm phrenic nerve preparations in vitro

Comparison

Solutions containing calcium and magnesium, with… vs Solutions with no added calcium or varying…

Design

Preclinical

Authors

JHJ. I. HubbardUniversity of North Texas at Dallas SJS. F. JonesAustralian National University ELE. M. LandauAustralian National University

Discussion

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Implication

No immediate clinical implications; leaves open roles for cation competition in human synaptic disorders.

Structured PICO

Population

Rat diaphragm phrenic nerve preparations in vitro

Intervention

Solutions containing calcium (10^-10 to 10^-2 M) and magnesium (similar range), with EDTA and EGTA buffers

Comparator

Solutions with no added calcium or varying concentrations of calcium and magnesium

Outcome

Frequency of miniature end-plate potentials (m.e.p.p.s)surrogate

Calcium and magnesium compete for the same nerve terminal receptor sites to allosterically activate the spontaneous release mechanism of neurotransmitters.

Cite This Study

Hubbard et al. (1968) studied this question.

synapsesocial.com/papers/6a7082ecc92390ac2d07ca77 https://doi.org/10.1113/jphysiol.1968.sp008413

View Full Paper

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On the mechanism by which calcium and magnesium affect the spontaneous release of transmitter from mammalian motor nerve terminals

Discussion

Member takes

Implication

Structured PICO

Cite This Study

On the mechanism by which calcium and magnesium affect the spontaneous release of transmitter from mammalian motor nerve terminals

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider