Population
Skinned fibres from the extensor digitorum longus muscle of rat
Comparison
Alterations in intracellular [Mg2+] and pH vs Different concentrations of [Mg2+] and pH levels
Design
Preclinical
Authors
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May distinguish Mg2+- versus pH-mediated muscle dysfunction; leaves open translation to human myopathies or fatigue.
In mammalian skeletal muscle, elevated intracellular magnesium potently inhibits depolarization-induced calcium release, whereas low pH does not prevent release but reduces calcium-activated force.
Lamb et al. (1994) studied this question.
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