Key result
Intracellular Mg2+ binds to and strongly inhibits Ca2+ release channels in skeletal muscle, an inhibition that may be removed during excitation by inducing Mg2+ dissociation.
Proposes a mechanism where excitation triggers Ca2+ release in skeletal muscle by inducing the dissociation of inhibitory Mg2+ from Ca2+ release channels.
Hypothesis-generating for skeletal muscle Ca2+ release; leaves open relevance to human excitation-contraction coupling or therapies.
In skeletal muscle, how excitation rapidly triggers Ca2+ release from internal stores is not known exactly. In addition to its many other roles, intracellular Mg2+ binds to the Ca2+ release channels and strongly inhibits their opening. Excitation may actually remove this inhibition by inducing dissociation of Mg2+.
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Lamb et al. (1992) studied this question. Intracellular Mg2+ binds to and strongly inhibits Ca2+ release channels in skeletal muscle, an inhibition that may be removed during excitation by inducing Mg2+ dissociation.
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