May 1, 1968The Journal of PhysiologyOpen Access

On the mechanism by which calcium and magnesium affect the release of transmitter by nerve impulses

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Population

Neuromuscular junctions in the rat diaphragm in vitro

Comparison

Exposure to solutions with calcium… vs Varying concentrations of calcium and magnesium

Design

Preclinical

Authors

JHJ. I. HubbardUniversity of North Texas at Dallas SJS. F. JonesAustralian National University ELE. M. LandauAustralian National University

Discussion

Member takes

Implication

No immediate clinical implications; leaves open whether magnesium-calcium competition at presynaptic sites affects human neuromuscular transmission.

Structured PICO

Population

Neuromuscular junctions in the rat diaphragm in vitro

Intervention

Exposure to solutions with calcium concentrations between 0.05 and 10 mM and magnesium concentrations between 0.1 and 12.5 mM

Comparator

Varying concentrations of calcium and magnesium

Outcome

Quantal content of end-plate potentials (e.p.p.s)surrogate

This preclinical study demonstrates that calcium and magnesium compete at three sites in the nerve terminal membrane to regulate neurotransmitter release.

Cite This Study

Hubbard et al. (1968) studied this question.

synapsesocial.com/papers/6a722599febe604dd70a7535 https://doi.org/10.1113/jphysiol.1968.sp008495

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Implication

No immediate clinical implications; leaves open whether magnesium-calcium competition at presynaptic sites affects human neuromuscular transmission.

On the mechanism by which calcium and magnesium affect the release of transmitter by nerve impulses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

On the mechanism by which calcium and magnesium affect the release of transmitter by nerve impulses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider