July 1, 1986The Journal of PhysiologyOpen Access

Effects of calcium and magnesium on transmitter release at Ia synapses of rat spinal motoneurones in vitro.

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Population

Lumbar spinal cord excised from neonatal rats

Comparison

Varying concentrations of external Ca2+ and Mg2+ vs Different concentrations of Ca2+ and Mg2+

Design

Preclinical

Authors

MKM. KunoGifu University Hospital TTTomoyuki TakahashiKurume University

Discussion

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Implication

Supports competitive Ca-Mg interaction at physiological levels; leaves open translation to human synaptic or neuromuscular disorders.

Structured PICO

Population

Lumbar spinal cord excised from neonatal rats

Intervention

Varying concentrations of external Ca2+ (0.5-12 mM) and Mg2+ (1-5 mM)

Comparator

Different concentrations of Ca2+ and Mg2+

Outcome

Amplitude and latency of monosynaptic excitatory post-synaptic potentials (e.p.s.p.s)surrogate

At near-normal levels of external calcium, the effects of calcium and magnesium on e.p.s.p. amplitude are accounted for entirely by their competitive interaction for the probability of transmitter release.

Cite This Study

Kuno et al. (1986) studied this question.

synapsesocial.com/papers/6a722596febe604dd70a7519 https://doi.org/10.1113/jphysiol.1986.sp016169

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Effects of calcium and magnesium on transmitter release at Ia synapses of rat spinal motoneurones in vitro.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of calcium and magnesium on transmitter release at Ia synapses of rat spinal motoneurones in vitro.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider