Key result
Injection of Mg2+ into spinal motoneurons of cats increases neuronal excitability and causes depolarization, likely by competing with Ca2+ and reducing K+ membrane conductance.
Why the study?
Does intracellular Mg2+ increase neuronal excitability in spinal motoneurons of cats?
Population
Spinal motoneurons of cats
Design
Preclinical
Authors
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May modulate motoneuron excitability via Ca2+/Mg2+ ratio in cats; leaves open relevance to human neurology.
Does intracellular Mg2+ increase neuronal excitability in spinal motoneurons of cats?
Intracellular Mg2+ increases neuronal excitability by decreasing K+ membrane conductance, suggesting neuronal excitability can be regulated by the ratio of internal free Ca2+/Mg2+.
Krnjević et al. (1976) studied this question. Intracellular Mg2+ injection was evaluated on Neuronal excitability and membrane conductance. Injection of Mg2+ into spinal motoneurons of cats increases neuronal excitability and causes depolarization, likely by competing with Ca2+ and reducing K+ membrane conductance.
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