Key result
Long-term treatment with amlodipine plus olmesartan medoxomil, up-titrated with hydrochlorothiazide as needed, allowed 66.7% of patients to achieve their blood pressure goal.
Why the study?
Does long-term treatment with amlodipine and olmesartan medoxomil (with optional hydrochlorothiazide) improve blood pressure goal achievement in patients with hypertension?
RCT (n=1,684)
Open-label
Does long-term treatment with amlodipine and olmesartan medoxomil (with optional hydrochlorothiazide) improve blood pressure goal achievement in patients with hypertension?
Long-term combination therapy with amlodipine and olmesartan, with optional hydrochlorothiazide up-titration, effectively lowers blood pressure and helps the majority of hypertensive patients achieve their BP goals.
Answers are grounded in this paper and cite their sources.
May support combination therapy for BP control in practice; extends observational data but leaves open randomized confirmation.
J Clin Hypertens (Greenwich). 2009;11:475-482. (c) 2009 Wiley Periodicals, Inc.The authors report on the 44-week open-label extension of the 8-week, double-blind Combination of Olmesartan Medoxomil and Amlodipine Besylate in Controlling High Blood Pressure (COACH) trial in 1684 patients. Initial therapy was amlodipine (AML) plus olmesartan medoxomil (OM) 5+40 mg/d, up-titrated to AML+OM 10+40 mg/d plus hydrochlorothiazide (HCTZ) 12.5 mg then 25 mg if patients did not achieve blood pressure (BP) goal (<140/90 mm Hg or <130/80 mm Hg in patients with diabetes). Baseline mean BP decreased from 164/102 mm Hg to 131/82 mm Hg at end of study, with an overall 66.7% of patients, including those with diabetes, achieving BP goal. The BP goal achievement was 80% for AML+OM 5+40 mg/d, 70.6% for AML+OM 10+40 mg/d, 66.6% for AML+OM+HCTZ 10+40+12.5 mg/d, and 46.3% for AML+OM+HCTZ 10+40+25 mg/d. Study medication was safe and well tolerated. Combination antihypertensive therapy with AML+OM+/-HTCZ, up-titrated as necessary, allowed a majority of patients to achieve BP goal.
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Chrysant et al. (2009) conducted an RCT in Hypertension (n=1,684). Amlodipine plus olmesartan medoxomil was evaluated on Blood pressure goal achievement (<140/90 mm Hg or <130/80 mm Hg in patients with diabetes). Long-term treatment with amlodipine plus olmesartan medoxomil, up-titrated with hydrochlorothiazide as needed, allowed 66.7% of patients to achieve their blood pressure goal.
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