Why the study?
Does combination therapy with olmesartan and amlodipine improve the achievement of blood pressure goals in patients with hypertension?
Does combination therapy with olmesartan and amlodipine improve the achievement of blood pressure goals in patients with hypertension?
Combination therapy with olmesartan and amlodipine is effective in helping hypertensive patients achieve their blood pressure goals.
May support olmesartan-amlodipine for BP goal attainment; leaves open head-to-head RCTs versus alternatives.
BACKGROUND: Combination therapy with antihypertensive agents utilises different mechanisms of action and may be responsible for a more effective decrease in blood pressure. OBJECTIVE: To review the recently published trials on efficacy and safety of the combination therapy with olmesartan and amlodipine. RESULTS: The double-blind American COACH (Combination of Olmesartan Medoxomil and Amlopdine Besylate in Controlling High Blood Pressure) study (2008) showed in 1,940 patients that after eight weeks of treatment the BP goals were most frequently achieved in the 'combination therapy group', with 56.3% (54.1-58.5%) and 54.0% (51.8-56.2%) of patients reaching adequate blood pressure of.
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Niemeijer et al. (2009) studied this question.
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